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Shirotani est un jeune homme brillant atteint de mysophobie (peur d'être contaminé par des microbes). Quand le chef d'entreprise pour lequel il travaille est victime d'un accident, il rencontre Kurose, un jeune homme qui lui conseille de se faire soigner et lui laisse la carte d'une clinique psychiatrique. Le lendemain, Shirotani se rend à la clinique et comprend que Kurose est un des psychiatres qui y travaillent. Les deux hommes noueront alors une relation qui dépasse bientôt le cadre médecin-patient.
Yuzu est une jeune fille à la mode, énergique et enthousiaste qui veut vivre pleinement sa vie. Elle ne connait pas l'amour et va jusqu'à cacher à ses amis son inexpérience derrière des mensonges pour bien paraître. Suite au remariage de sa mère, elle se retrouve dans une nouvelle école très restrictive réservée aux filles. Le jour de la rentrée, Yuzu se dispute avec Mei, qui n'est autre que la présidente du conseil des élèves et. sa nouvelle demi-soeur ! Face à cette situation, Yuzu ne sait pas comment réagir. Réussira-t-elle à se faire à sa nouvelle vie ? Arrivera-t-elle à s'entendre avec sa demi-soeur ?
Katsuya Asano, un profiler formé aux Etats-Unis, est amené à travailler pour la police de Tokyo afin de fournir le profil d'un tueur en série qui sévit depuis plusieurs années. Grâce à son aide, l'opération est une réussite et Shinohara Keiji est enfin arrêté. Obnubilé par la personne qui est à l'origine de son arrestation, ce dernier accepte de faire des aveux complets, mais à la condition que Katsuya soit celui qui les recueille. À peine le jeune profiler vient-il d'accepter qu'il est tourmenté nuit après nuit par le même cauchemar : un homme dont il ne voit pas le visage le retient prisonnier et le torture tout en lui murmurant à l'oreille qu'il l'aime. La frontière entre rêve et réalité s'effondre alors brutalement pour lui...
