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Twilight, le plus grand espion du monde, doit pour sa nouvelle mission créer une famille de toutes pièces afin de pouvoir s'introduire dans la plus prestigieuse école de l'aristocratie. Totalement dépourvu d'expérience familiale, il va adopter une petite fille en ignorant qu'elle est télépathe, et s'associer à une jeune femme timide, sans se douter qu'elle est une redoutable tueuse à gages. Ce trio atypique va devoir composer pour passer inaperçu, tout en découvrant les vraies valeurs d'une famille unie et aimante.
L'histoire se déroule en Allemagne, en 1986, à Düsseldorf. Kenzo Tenma, le personnage principal, est un jeune neurochirurgien très talentueux, destiné à une brillante carrière et fiancé à la fille du directeur de l'hôpital, Eva Heinman. Mais un jour il refuse de soigner le maire et préfère soigner un garçon blessé d'une balle dans la tête. Sa sœur jumelle est aussi internée dans l'hôpital car elle est très choquée. Leurs parents (adoptifs) ont été assassinés sauvagement. Le garçon s'en sort, mais le maire meurt, faute de soins. Tenma est alors rétrogradé par le directeur de l'hôpital et Eva le quitte. Peu de temps après, le garçon et sa sœur disparaissent. Neuf ans plus tard alors que Tenma est sur le point de devenir le directeur d'hôpital, il est accusé de meurtre qui ont en fait été commis par Johann, ce garçon de 11 ans qu'il avait sauvé. Dès lors l'inspecteur Rünge, un homme de caractère et de confiance prend en charge l'enquête. Il poursuit Tenma sans relâche tandis que ce dernier poursuit Johann ; car Tenma, qui se demande s'il n'a pas sauvé un "Monstre", sait que les meurtres sont "l'œuvre" de son ancien patient.
Renversé par un camion en rentrant de l'école, le jeune Kei meurt sur le coup. Mais quelques instant plus tard, il ressuscite mystérieusement. Dès lors, sa vie de lycéen bascule. Une étrange organisation gouvernementale tente par tous les moyens de le capturer afin de mener des expériences scientifiques sur lui. Rapidement, il apprend qu'il n'est pas le seul être dans cette situation périlleuse, et qu'il semble être ce que certains nomment un "Ajin". Personne ne sait exactement comment ils sont apparus ni pourquoi ils existent. Mais les services spéciaux du gouvernement sont prêts à user de tous les moyens pour le découvrir, car rien à leurs yeux n'est plus dangereux pour l'humanité. qu'un être immortel !
