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Kirihito Osanai, un jeune et brillant médecin, est confronté à une mystérieuse maladie qui frappe les habitants d'un petit village des montagnes de l'île de Shikoku : les malades se transforment en chien, avant de décéder. Pour les villageois, c'est une possession par la divinité du lieu : le dieu chien Monmô. Pour Kirihito, il doit s'agir d'une endémie dont la cause est écologique.
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