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Yû, nouvelle élève de 1re année au lycée Tohmi Higashi, n'est jamais tombée amoureuse. Un jour, elle aperçoit Tôko Nami, membre du conseil des élèves, en train de rejeter un garçon lui déclarant sa flamme. Yû pense avoir enfin trouvé quelqu'un comme elle. Quelqu'un qui n'a jamais connu l'amour et qu'aucune déclaration n'a jamais ému. Mais elle va vite déchanter lorsque cette dernière lui adresse ces quelques mots... « Je crois que je pourrais t'aimer, toi. »
Shirotani est un jeune homme brillant atteint de mysophobie (peur d'être contaminé par des microbes). Quand le chef d'entreprise pour lequel il travaille est victime d'un accident, il rencontre Kurose, un jeune homme qui lui conseille de se faire soigner et lui laisse la carte d'une clinique psychiatrique. Le lendemain, Shirotani se rend à la clinique et comprend que Kurose est un des psychiatres qui y travaillent. Les deux hommes noueront alors une relation qui dépasse bientôt le cadre médecin-patient.
Yuzu est une jeune fille à la mode, énergique et enthousiaste qui veut vivre pleinement sa vie. Elle ne connait pas l'amour et va jusqu'à cacher à ses amis son inexpérience derrière des mensonges pour bien paraître. Suite au remariage de sa mère, elle se retrouve dans une nouvelle école très restrictive réservée aux filles. Le jour de la rentrée, Yuzu se dispute avec Mei, qui n'est autre que la présidente du conseil des élèves et. sa nouvelle demi-soeur ! Face à cette situation, Yuzu ne sait pas comment réagir. Réussira-t-elle à se faire à sa nouvelle vie ? Arrivera-t-elle à s'entendre avec sa demi-soeur ?
