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L'histoire se déroule en Allemagne, en 1986, à Düsseldorf. Kenzo Tenma, le personnage principal, est un jeune neurochirurgien très talentueux, destiné à une brillante carrière et fiancé à la fille du directeur de l'hôpital, Eva Heinman. Mais un jour il refuse de soigner le maire et préfère soigner un garçon blessé d'une balle dans la tête. Sa sœur jumelle est aussi internée dans l'hôpital car elle est très choquée. Leurs parents (adoptifs) ont été assassinés sauvagement. Le garçon s'en sort, mais le maire meurt, faute de soins. Tenma est alors rétrogradé par le directeur de l'hôpital et Eva le quitte. Peu de temps après, le garçon et sa sœur disparaissent. Neuf ans plus tard alors que Tenma est sur le point de devenir le directeur d'hôpital, il est accusé de meurtre qui ont en fait été commis par Johann, ce garçon de 11 ans qu'il avait sauvé. Dès lors l'inspecteur Rünge, un homme de caractère et de confiance prend en charge l'enquête. Il poursuit Tenma sans relâche tandis que ce dernier poursuit Johann ; car Tenma, qui se demande s'il n'a pas sauvé un "Monstre", sait que les meurtres sont "l'œuvre" de son ancien patient.
Pour se venger des coups qu'il a reçus, Riku boxe le corps de son père qui vient de se pendre. Il veut vivre avec sa mère, mais il découvre avec horreur qu'elle est dépendante d'un dealer brutal et sadique. Empli de rage face à toutes ces tragédies, Riku demande à un ancien boxeur devenu yakuza de lui apprendre à se battre pour défendre ceux qu'il aime. L'ex-champion refuse mais l'envoie chez son ancien entraîneur de boxe. Le jeune garçon trouvera-t-il sa voie dans ce sport âpre et violent ?
Elevé au fin fond de la foret, Mash Burnedead partage ses journées entre séances de musculation et dégustation de choux à la crème. Mais un jour, un agent de police découvre son secret : il est né sans pouvoirs magiques, ce qui est puni de mort ! Pour survivre, il va devoir postuler à Easton, une prestigieuse académie de magie, et en devenir le meilleur élève... La magie n’a plus ; qu’a bien se tenir : avec sa musculature affûtée et sa force hors du commun, Mash compte bien pulvériser tous les sorts et briser les codes de cette société !
