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Shirotani est un jeune homme brillant atteint de mysophobie (peur d'être contaminé par des microbes). Quand le chef d'entreprise pour lequel il travaille est victime d'un accident, il rencontre Kurose, un jeune homme qui lui conseille de se faire soigner et lui laisse la carte d'une clinique psychiatrique. Le lendemain, Shirotani se rend à la clinique et comprend que Kurose est un des psychiatres qui y travaillent. Les deux hommes noueront alors une relation qui dépasse bientôt le cadre médecin-patient.
Uenoyama est un lycéen féru de guitare et de basket. Seulement, la passion qui l'animait semble s'être éteinte pour laisser place à un quotidien morne, rythmé par de simples siestes. Un jour, il tombe sur Mafuyu, qui s'est endormi à l'un de ses endroits favoris, une superbe guitare Gibson serrée contre lui. Ce dernier le supplie alors de la réparer et de lui apprendre à en jouer. Si Uenoyama refuse catégoriquement au début, il finit par l'aider et va même jusqu'à l'intégrer dans son groupe. Il découvre derrière la candeur de Mafuyu un talent incroyable et bouleversant. Malheureusement, ce dernier est également hanté par un lourd traumatisme qui l'empêche de s'exprimer pleinement...
Yuzu est une jeune fille à la mode, énergique et enthousiaste qui veut vivre pleinement sa vie. Elle ne connait pas l'amour et va jusqu'à cacher à ses amis son inexpérience derrière des mensonges pour bien paraître. Suite au remariage de sa mère, elle se retrouve dans une nouvelle école très restrictive réservée aux filles. Le jour de la rentrée, Yuzu se dispute avec Mei, qui n'est autre que la présidente du conseil des élèves et. sa nouvelle demi-soeur ! Face à cette situation, Yuzu ne sait pas comment réagir. Réussira-t-elle à se faire à sa nouvelle vie ? Arrivera-t-elle à s'entendre avec sa demi-soeur ?
