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Shirotani est un jeune homme brillant atteint de mysophobie (peur d'être contaminé par des microbes). Quand le chef d'entreprise pour lequel il travaille est victime d'un accident, il rencontre Kurose, un jeune homme qui lui conseille de se faire soigner et lui laisse la carte d'une clinique psychiatrique. Le lendemain, Shirotani se rend à la clinique et comprend que Kurose est un des psychiatres qui y travaillent. Les deux hommes noueront alors une relation qui dépasse bientôt le cadre médecin-patient.
Yuzu est une jeune fille à la mode, énergique et enthousiaste qui veut vivre pleinement sa vie. Elle ne connait pas l'amour et va jusqu'à cacher à ses amis son inexpérience derrière des mensonges pour bien paraître. Suite au remariage de sa mère, elle se retrouve dans une nouvelle école très restrictive réservée aux filles. Le jour de la rentrée, Yuzu se dispute avec Mei, qui n'est autre que la présidente du conseil des élèves et. sa nouvelle demi-soeur ! Face à cette situation, Yuzu ne sait pas comment réagir. Réussira-t-elle à se faire à sa nouvelle vie ? Arrivera-t-elle à s'entendre avec sa demi-soeur ?
Miyano est un lycéen fan de mangas boy’s love. Et surtout, il est très complexé par son visage aux traits efféminés. Mais un jour, alors qu’il assiste à une bagarre, un de ses aînés intervient pour éviter que la situation ne tourne au vinaigre. Ce dernier, prénommé Sasaki, commence très vite à éprouver de l’affection pour son camarade. Cherchant à le comprendre et à le connaître, il découvre l’intérêt que Miyano porte pour les mangas boy’s love... Sans préjugé, il va alors également commencer à essayer d’en lire. Et si c’était le début d’une belle histoire d’amour ? Dans Sasaki et Miyano, véritable manga hybride et énorme succès au Japon, suivez le quotidien empli de douceur de deux adolescents qui apprennent à se connaître...
