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Les USA sont devenues une terre mystérieuse et surtout dangereuse après s'être armée puis fermée au reste du monde, sans aucune explication, il y a plus de trente ans. Lorsqu'une équipe à la recherche d'un remède contre une pandémie mondiale franchit les frontières américaines, elle se retrouve rapidement acculée afin de lutter pour sa survie sur ce continent dorénavant perdu, étrange et mortel !
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