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L'histoire se déroule en Allemagne, en 1986, à Düsseldorf. Kenzo Tenma, le personnage principal, est un jeune neurochirurgien très talentueux, destiné à une brillante carrière et fiancé à la fille du directeur de l'hôpital, Eva Heinman. Mais un jour il refuse de soigner le maire et préfère soigner un garçon blessé d'une balle dans la tête. Sa sœur jumelle est aussi internée dans l'hôpital car elle est très choquée. Leurs parents (adoptifs) ont été assassinés sauvagement. Le garçon s'en sort, mais le maire meurt, faute de soins. Tenma est alors rétrogradé par le directeur de l'hôpital et Eva le quitte. Peu de temps après, le garçon et sa sœur disparaissent. Neuf ans plus tard alors que Tenma est sur le point de devenir le directeur d'hôpital, il est accusé de meurtre qui ont en fait été commis par Johann, ce garçon de 11 ans qu'il avait sauvé. Dès lors l'inspecteur Rünge, un homme de caractère et de confiance prend en charge l'enquête. Il poursuit Tenma sans relâche tandis que ce dernier poursuit Johann ; car Tenma, qui se demande s'il n'a pas sauvé un "Monstre", sait que les meurtres sont "l'œuvre" de son ancien patient.
Autour du lycée de Jin, les disparitions de femmes se multiplient... Le jeune garçon vit pourtant dans un quartier huppé grâce à la réussite de son père, P.-D.G. d'une grande entreprise. On pourrait croire qu'il a tout pour être heureux, mais l'adolescent souffre de l'absence de sa mère et d'une vie solitaire. Son seul repère est son père : toujours prêt à aider son prochain, il est connu pour ses actions caritatives. Pourtant, ses airs avenants dissimulent un tueur en série à la cruauté sans limites... C'est lui qui se cache derrière les disparitions ! Et Jin est bien placé pour le savoir, puisqu'il joue depuis des années le rôle d'appât afin d'assurer sa propre survie ! Sa mission ? Attirer les victimes et les assommer à coups de masse avant de les livrer à leur bourreau... Mais quand la prochaine cible désignée est la nouvelle élève de sa classe, la seule à lui avoir jamais porté de l'intérêt, c'est le déclic. Pour la première fois, il décide de se rebeller : qui sortira vivant de cet implacable duel père-fils ? Plongez dans un thriller psychologique sans concession ! De page en page, le suspense se fait toujours plus haletant au fil d'une intrigue déroulée de main de maître.
Rapatrié d'Afghanistan à cause d'une blessure et de troubles psychologiques, le Dr. Watson retrouve un vieil ami de l'époque de la faculté de médecine qui lui présente son futur colocataire. D'un seul coup d'oeil, cette personne devine qu'il s'agit d'un médecin militaire de retour du Moyen-Orient, qu'un de ses proches est victime d'alcoolisme ou encore qu'il est suivi par un thérapeute. Le nom de ce colocataire ? Sherlock Holmes.
