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L'histoire se déroule en Allemagne, en 1986, à Düsseldorf. Kenzo Tenma, le personnage principal, est un jeune neurochirurgien très talentueux, destiné à une brillante carrière et fiancé à la fille du directeur de l'hôpital, Eva Heinman. Mais un jour il refuse de soigner le maire et préfère soigner un garçon blessé d'une balle dans la tête. Sa sœur jumelle est aussi internée dans l'hôpital car elle est très choquée. Leurs parents (adoptifs) ont été assassinés sauvagement. Le garçon s'en sort, mais le maire meurt, faute de soins. Tenma est alors rétrogradé par le directeur de l'hôpital et Eva le quitte. Peu de temps après, le garçon et sa sœur disparaissent. Neuf ans plus tard alors que Tenma est sur le point de devenir le directeur d'hôpital, il est accusé de meurtre qui ont en fait été commis par Johann, ce garçon de 11 ans qu'il avait sauvé. Dès lors l'inspecteur Rünge, un homme de caractère et de confiance prend en charge l'enquête. Il poursuit Tenma sans relâche tandis que ce dernier poursuit Johann ; car Tenma, qui se demande s'il n'a pas sauvé un "Monstre", sait que les meurtres sont "l'œuvre" de son ancien patient.
Naoki Urasawa est de retour chez Kana avec sa toute nouvelle série phare : Asadora ! Urasawa parvient à rendre palpitant le mélange a priori improbable du récit de la vie tumultueuse d'une jeune fille, démarrant en 1959, avec une histoire de monstre godzillesque attaquant le Japon de nos jours. C'est addictif dès les premières pages ! Avec ce récit, on entre à nouveau avec bonheur dans le cinéma d'Urasawa, comme on le ferait dans celui d'un Tarantino !
Uenoyama est un lycéen féru de guitare et de basket. Seulement, la passion qui l'animait semble s'être éteinte pour laisser place à un quotidien morne, rythmé par de simples siestes. Un jour, il tombe sur Mafuyu, qui s'est endormi à l'un de ses endroits favoris, une superbe guitare Gibson serrée contre lui. Ce dernier le supplie alors de la réparer et de lui apprendre à en jouer. Si Uenoyama refuse catégoriquement au début, il finit par l'aider et va même jusqu'à l'intégrer dans son groupe. Il découvre derrière la candeur de Mafuyu un talent incroyable et bouleversant. Malheureusement, ce dernier est également hanté par un lourd traumatisme qui l'empêche de s'exprimer pleinement...
