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De nuit, à Chicago, un groupe d'étudiants s'introduit dans un laboratoire afin d'y libérer des animaux. Mais, malades, ceux ci ont été transférés pour éviter la contagion. Brian, journaliste infiltré dans le groupe, mène son enquête et découvre que l'armée est impliquée. Dans un État voisin, un chien enragé attaque bêtes et propriétaire...
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