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Province de Shizuoka, au cœur des années 1950. C'est dans ce coin de campagne que moi, médecin grisonnant, je me suis établi avec ma femme. J'ai aussi une nièce : Honami. Elle vit normalement à Tokyo, mais ne manque jamais une occasion de prendre la fuite pour débarquer ici à l'improviste. En général, ces escapades ne durent jamais longtemps, mais cette fois-ci, elle ne semble pas disposée à repartir. À force d'insister pour connaître ses intentions, elle me confe son rêve de poursuivre ses études afin de devenir vétérinaire. Je décide alors de la soutenir dans cette voie…
Pour Suzuki et Takagi, élèves de première, le temps semble s’être figé : le 31 août recommence inlassablement, et ils sont les seuls à se souvenir des journées qui se répètent. Selon eux, ils seraient bloqués ce jour-ci car Suzuki n'a pas pu accomplir tout ce qu'il a voulu faire cet été... notamment une chose particulièrement importante. Ensemble, ils vont tenter de briser la boucle, condamnés à revivre encore et encore cette même journée d'ici là...
Rencontre mortelle à Alcatraz ! Le chaos règne à San Francisco : tandis que Claire Redfield examine une orque victime d'un monstre marin gigantesque, son frère Chris enquête avec Jill Valentine sur une mystérieuse épidémie de zombies. De son côté, Leon Kennedy part à la recherche d'un scientifique enlevé par un groupe armé. Si ces événements ne semblent pas liés, ils pointent pourtant tous vers un même lieu : l'île d'Alcatraz. Une fois sur place les quatre agents vont faire face à des horreurs indicibles...
