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Deux frères orphelins sont accueillis dans la famille Moriarty, grâce aux ambitions cachées du fils aîné Moriarty, Albert. Ce dernier abhorre l'aristocratie à laquelle il appartient et le système social qui régit la société britannique. Albert a vu en l'aîné l'intelligence et le charisme dont il avait besoin pour accomplir son rêve de nettoyer la société de ces "êtres inutiles et sales". Albert propose de leur offrir sa richesse et son influence à condition que les garçons mettent leur intelligence au service de son rêve. 13 ans plus tard, à côté de leurs activités officielles, les frères Moriarty sont devenus des "conseillers privés". Avec William à leur tête, ils aident les gens du peuple, victimes d'injustices, à se venger des riches qui les ont fait souffrir.
Six mois se sont écoulés depuis la catastrophe, impliquant Kyogre et Groudon. Rouge et Bleu embraquent pour les îles de Sevii sur les traces du Professeur Chen. Ils vont être témoins d'une terrible tragédie dont est victime leur amie Verte. C'est le début d'une nouvelle grande aventure où nos héros vont devoir déjouer le sombre complot d'un vieil ennemi qu'ils pensaient disparu...
L'histoire se déroule en Allemagne, en 1986, à Düsseldorf. Kenzo Tenma, le personnage principal, est un jeune neurochirurgien très talentueux, destiné à une brillante carrière et fiancé à la fille du directeur de l'hôpital, Eva Heinman. Mais un jour il refuse de soigner le maire et préfère soigner un garçon blessé d'une balle dans la tête. Sa sœur jumelle est aussi internée dans l'hôpital car elle est très choquée. Leurs parents (adoptifs) ont été assassinés sauvagement. Le garçon s'en sort, mais le maire meurt, faute de soins. Tenma est alors rétrogradé par le directeur de l'hôpital et Eva le quitte. Peu de temps après, le garçon et sa sœur disparaissent. Neuf ans plus tard alors que Tenma est sur le point de devenir le directeur d'hôpital, il est accusé de meurtre qui ont en fait été commis par Johann, ce garçon de 11 ans qu'il avait sauvé. Dès lors l'inspecteur Rünge, un homme de caractère et de confiance prend en charge l'enquête. Il poursuit Tenma sans relâche tandis que ce dernier poursuit Johann ; car Tenma, qui se demande s'il n'a pas sauvé un "Monstre", sait que les meurtres sont "l'œuvre" de son ancien patient.
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